Bone Abstracts

Introduction: Osteoclasts are the only cells with the capacity to degrade mineralized matrices, such as bone and calcified cartilage. During bone remodeling, osteoclasts secrete protons to achieve the acidic dissolution of hydroxyapatite to make bone collagen amenable to digestion by the proteases they produce. This requires the sealing zone, a ring of densely packed podosomes that surrounds the ruffled border, which is the secretion apparatus of the bone resorbing osteoclasts...